On the contrary, ZNF268 expression was negatively correlated to the infiltration level of Treg cells (P < 0.001; Figure 3i) and NK CD56 bright cells (Figure S1C) The above results provided evidence that ZNF268 can activate the immune response in ccRCC to inhibit tumor growth. The gene discussed is ZNF268; the disease is nonpapillary renal cell carcinoma.