To further investigate whether the stability of SLC25A21 mRNA is regulated by SLC25A21‐AS1, ESCC cells were treated with α‐amanitin (50 μg/ml) for 8, 16, and 24 h; the data of RT‐qPCR showed that SLC25A21‐AS1 overexpression significantly mitigated the degradation of SLC25A21 mRNA (Figure 6F). Here, PTGDR is linked to esophageal squamous cell carcinoma.