SIRT3 and acute kidney injury: In line with this observation, administration of resveratrol, a Sirt1 activator, inhibits AKI and improves renal function15; increased expression of histone deacetylase SIRT3, another form of SIRT family that is specifically expressed in the mitochondria, can also protect against cisplatin‐induced kidney damage by improving the dynamics of cell mitochondria.16, 17, 18