Here, we investigated the effects of PC exosomes on adipocytes and found that (i) Pancreatic cancer exosomes could disrupt the lipid composition of adipocytes and a remarkable down-regulation in TG was observed; (ii) PC exosomes treatment significantly reduced the formation of Large LDs and increased the number of Small LD in adipocytes, and reduced adipocytes size after injection in mice, suggesting that PC exosomes could promote lipolysis in adipocytes both in vitro and in vivo; (iii) PC exosomes increased inflammatory factor IL-6 production which in turn promoted lipolysis in adipocytes. Here, IL6 is linked to familial pancreatic carcinoma.