By contrast to subjects without venous ulcers, those with varicose ulcers go through a notable increase in the ratio of gelatinases (MMP-2 and MMP-9) and their inhibitors (TIMP metallopeptidase inhibitor 1 (TIMP-1) and TIMP metallopeptidase inhibitor 2 (TIMP-2)), but the ratio of MMP-2 and TIMP-2 is lowered in subjects whose ulcers have been repressed [66]. Here, TIMP1 is linked to ulcer disease.