In addition, in response to coculture with FRα-expressing BC cells, the T lymphocytes activated by SmartDC-FRα substantially upregulated IFN-γ production, whereas a very low level of IFN-γ was detected when the activated T lymphocytes were cocultured with FRα-negative MCF10A cells (Figure 5(c)). The gene discussed is IFNG; the disease is breast cancer.