FOLR1 and breast cancer: However, reduction in size and breakage of MCF-7 and MDA-MB-231 spheroids were observed after coculturing with T lymphocytes activated by SmartDC-FRα, but not with unactivated T lymphocytes or T lymphocyte activated by SmartDC-iRFP (Figure 6), which demonstrate the specific cytotoxicity against FRα-expressing BC cells of T lymphocytes activated by SmartDC-FRα.