TMEM88 and neoplasm: During the research process of TMEM88, studies have pointed out that the C-terminal tripeptide Val-Trp-Val sequence of a subtype of TMEM88 CRA-a can bind to the PDZ domain of the scrambled protein and prohibit the Wnt/β-catenin signaling pathway, which exerts a nonnegligible effect in regulating tumor cell proliferation, metastasis and host antitumor immunity (22, 27, 58).