The correlation analysis results of clinicopathological characteristics showed that high expression of TMEM88 in the cytoplasm was directly correlated with the tissue differentiation, lymph node metastasis and tumor stage of NSCLC patients (P < 0.001, P = 0.032 and P = 0.012), but there was no obvious correlation with sex, age, or histological type (P = 1, P = 0.884 and P = 1). The gene discussed is TMEM88; the disease is non-small cell lung carcinoma.