TMEM88 and metastatic malignant neoplasm in the lymph nodes: One study found that cytoplasmic localization of TMEM88 was positively correlated with TNM stage and lymph node metastasis in triple-negative breast cancer, whereas nuclear localization was negatively correlated with lymph node metastasis in nontriple-negative breast cancer (30); in ovarian cancer, TMEM88 was found to downregulate the levels of c-Myc and Cyclin D1, thereby inhibiting the proliferation of ovarian cancer cells (19).