Immunofluorescence staining of 7 types of lung cancer cells (A549, LTE, SPC, H292, H1299, BE1 and LH7 cells) found that the content of TMEM88 was significantly higher than that in human bronchial epithelial cells (HBE), while TMEM88 was found in the other two lung cancer cell types (LK2 and H460 cells) and was interestingly lower than that in HBE cells, and TMEM88 was predominantly located on the cell membrane in all types of lung cancer cells studied. Here, TMEM88 is linked to lung carcinoma.