used an Illumina 450k DNA methylation array to detect methylated genes and levels in ovarian cancer xenografts and found that compared with platinum-sensitive transplanted tumors, the promoter region of the TMEM88 gene in platinum-resistant transplanted tumors in nude mice was significantly hypomethylated, while TMEM88 mRNA showed a substantial increase (19). This evidence concerns the gene TMEM88 and ovarian cancer.