In one study, research found that TMEM88 is closely relevant to the pathogenesis and development of bladder cancer, and inhibition of the TMEM88/Wnt axis can significantly affect abnormal bladder cancer cell proliferation and the regulation of the cell cycle (29), which suggests that targeting TMEM88 for bladder cancer research will be a new strategy and direction. Here, TMEM88 is linked to urinary bladder cancer.