BRCA2 and breast carcinoma: Approximately 5–10% of individuals that develop breast cancer are genetically predisposed to the disease, and, among these, 10–30% have been attributed to mutations in the tumor suppressor gene BRCA2. The penetrance of having BRCA2 mutations is severe – there is a 45-69% risk of developing breast cancer by 70-80 years of age for women carrying a pathogenic BRCA2 variant against a 13% risk for women in the general population (https://www.cancer.gov/about-cancer/causes-prevention/genetics/brca-fact-sheet#r4) (2).