BRCA2 and Fanconi anemia: si-RNA-mediated knockdown of BRCA2 or other proteins of the Fanconi Anemia pathway, inhibited clearance of mitochondria by Parkin-mediated mitophagy (32), suggesting an essential role of BRCA2 in mitochondria homeostasis (see also YEAST AS A MODEL TO STUDY BRCA2 FUNCTIONS AND CELL DEATH PROGRAMS below) and indicating that BRCA2 is essential for a cytoplasmic-localized function, i.e., mitophagy.