Upon infection, knockdown of SUMO-2/3, SUMO-activating E1 enzymes (AOS-1 and UBA2), SUMO-conjugating E2 enzyme (UBC9), and SENP1 significantly upregulated the colocalization with 0.17, 0.14, 0.29, 0.52, and 0.23 values of Pearson’s correlation coefficient as compared to MOCK, thus inducing phagolysosome fusion. Here, UBE2I is linked to infection.