Upon infection, knockdown of SUMO-2/3, SUMO-activating E1 enzymes (AOS-1 and UBA2), SUMO-conjugating E2 enzyme (UBC9), and SENP1 significantly upregulated the colocalization with 0.17, 0.14, 0.29, 0.52, and 0.23 values of Pearson’s correlation coefficient as compared to MOCK, thus inducing phagolysosome fusion. The gene discussed is SENP1; the disease is infection.