Single nucleotide polymorphisms (SNPs) in DDX58 (encoding RIG-I) and IFIH1 (encoding MDA5) were found in patients with autoimmune and autoinflammatory diseases, such as SLE, Aicardi-Goutières syndrome (AGS), T1D, psoriasis, and Singleton-Merten syndrome (SMS) (Table 1). The gene discussed is IFIH1; the disease is Smith-Magenis syndrome.