When these mice were crossed with mice carrying the STING loss-of-function mutation or treated with the STING palmitoylation inhibitor, they recovered from the IFN signature, indicating that the pathogenesis of COPA syndrome is associated with STING palmitoylation (Deng et al., 2020). The gene discussed is IFNA1; the disease is autoimmune interstitial lung disease-arthritis syndrome.