WEE1 and Insulin resistance: The possible explanation underlying the association between Aβ and glucose metabolism may include insulin resistance (Neth and Craft, 2017; Kellar and Craft, 2020), mitochondrial dysfunction (involving TCA cycle and oxidative phosphorylation system), reactive oxygen species, apoptosis, inflammatory factors, excitotoxicity, glycation end products, hyper-activation of some protein kinases and so on (Devi et al., 2006; Chen and Zhong, 2013).