NEFL and Alzheimer disease: With specific relevance to established biomarkers in use for AD/ADRD research, neurofilament light (NfL) has a biotemporal CV of 5.1% and a broad range in maximum and minimum values (Supplementary Figure S2), while YKL40 (CHI3L1) has a biotemporal CV of 7.26%, with a similar broad range of values (Supplementary Figure S2).