However, there was a modest and inverse correlation between anti-PAD2 antibody levels and disease severity, as measured by MSSS in a univariate analysis (τ = −0.145, p = 0.02) of all patients with MS, but this trend was not maintained in a multivariable model adjusting for age, sex, and treatment (Figure 3A). This evidence concerns the gene PADI2 and myeloid sarcoma.