JAK1 and gastric cancer: Including JAK1, JAK2, JAK3, and Tyk2, various JAKs are always activated by cytokines to mediate the gastric cancer cells progression, such as JAK1 kinase by IL-10 family cytokines, JAK2 kinase by G-CSF factor, Tyk2 kinase by cytokine IL-23, respectively (De Velasco et al., 2016; O'Shea et al., 2015).