Mayosi, B. M. et al. (2017) used WES to detect novel rare variants in patients with arrhythmogenic cardiomyopathy and found that CDH2 mutation changes the conserved amino acids of CDH2 protein. Since the relationship between CDH2 and PDA is unclear, additional studies are needed to determine how genetic perturbations of CDH2 contribute to PDA. Here, CDH2 is linked to Patent ductus arteriosus.