INS and prion disease: The top 10 enriched KEGG pathways of downregulated DEGs were mainly enriched in the MAPK signaling pathway, circadian rhythm, insulin signaling pathway, adipocytokine signaling pathway, Jak-STAT signaling pathway, cytokine–cytokine receptor interaction, toll-like receptor signaling pathway, neurotrophin signaling pathway, p53 signaling pathway, and prion diseases.