In our research, we used public cancer databases for data mining and found that most of the MS4A family genes exhibited high expression in glioma tissue compared with those in normal tissue; however, MS4A4A, MS4A4E, MS4A6A, MS4A7, TMEM176A, and TMEM176B showed good predictive power using ROC curve analysis. The gene discussed is TMEM176B; the disease is central nervous system cancer.