The “traditional protocol” revealed a mutation associated with OI in 148/199 (74.4%) patients (112 SNVs, 34 small indels, and 2 big deletions): 64 in COL1A1, 68 in COL1A2, 3 in CRTAP, 1 in FKBP10, 3 in IFITM5, 3 in LEPRE1, 1 in PLS3, 3 in SERPINF1, and 2 in WNT1. The gene discussed is CRTAP; the disease is osteogenesis imperfecta.