It is noteworthy that, based on KEGG Gene Set (hsa05202), HOXA9, HOXA10 and MEIS1 have association with differentiation resistance in KMT2A-MLLT1 (or MLL-ENL) T-ALL, while this same biological process has the involvement of PBX3, RUNX2, SMAD1, MEF2C, HOXA9 and HOXA10 in KMT2A-AFF1 (or MLL-AF4) B-ALL. This evidence concerns the gene RUNX2 and acute lymphoblastic leukemia.