ADIPOQ and Insulin resistance: Cornus officinalis Siebold & Zucc. [Cornaceae] extract can promote the expression of peroxisome proliferator-activated receptor γ (PPAR-γ) in adipocytes, increase the expression of recombinant glucose transporter 4 (GLUT4) and adiponectin, improve insulin resistance, and increase glucose utilization, ultimately achieving the effect of lowering the blood sugar levels (Kim et al., 2009).