ITGB2 and colorectal carcinoma: For Local-CRC, the HR-MUT group had significantly higher mutation frequency than the HR-WT group in Gli3 (42.9% vs. 3.6%), BRCA2 (42.9% vs. 0.0%), and ITGB2 (42.9% vs. 0.0%) (all p < 0.05; Figure 4A).