DLL4 and neoplasm: IFNγ-γ-mediated vascular inhibition is one of the important anti-tumor mechanisms of T cells (Qin and Blankenstein, 2000; Kammertoens et al., 2017), as it can reduce the expression of Dll4 signaling pathway in endothelial cells, destroy the connection between endothelial cells, and resist angiogenesis in tumor tissue (Deng et al., 2014).