Recent studies have reported that these flavonoids can promote the migration and invasion of extravillous trophoblast cells by increasing matrix metalloproteinase 9 (MMP9) expression and prevent miscarriage by activating Notch, AKT, and mitogen-activated protein kinase (MAPK) signaling pathways (Gao et al., 2018). This evidence concerns the gene AKT1 and Miscarriage.