In the colonic lamina propria of patients with IBD, Th17 cells highly express IL-8 and mediate the recruitment of tissue-infiltrating neutrophils, which have been proven to be the main producers of IL-23 in the intestine in an IL-8/CXCR1/CXCR2-dependent manner (Kvedaraite et al., 2016; Kvedaraite, 2021). The gene discussed is CXCL8; the disease is inflammatory bowel disease.