Previous studies showed that obesity causes alterations in cardiac energy metabolism in cardiomyocytes, particularly fatty acid metabolism [9, 10], and analysis has revealed that acyl-CoA synthetase long-chain family member 1 (ACSL-1) and glucose transporter member 4 (GLUT-4) may be the key proteins responsible for heart damage [11]. Here, ACSL1 is linked to obesity due to melanocortin 4 receptor deficiency.