For example, a recent study showed that the expression of regulatory T cells decreased in early-relapse HCC (25), but it has also been reported that CXCL10/CXCR3 signaling or deficits in CD4 cytotoxic T cells could induce regulatory T cell mobilization to promote liver tumor recurrence (55, 56). Here, CXCR3 is linked to hepatocellular carcinoma.