ITGB2 and Ito hypomelanosis: Despite, the significant impairment of the early innate immune response mediated by PMN, the overall survival of A. fumigatus infected CD18Ly6G cKO mice was not significantly impaired, suggesting that CD18 despite its pivotal immunoregulatory function might not be critical for the long-term control of IPA or that the residual β2-integrin expression found on PMN of CD18Ly6G cKO mice was sufficient for PMN-mediated pathogen clearance in some mice.