CRIPTO3 and candidiasis: These findings are again consistent with previous reports, which demonstrated that CD11b−/− mice displayed an attenuated PMN killing activity and increased fungal burdens in a mouse model of candidiasis, thus underpinning the pivotal role of β2 integrins for antifungal effector mechanisms (64), such as CR3-mediated phagocytosis, NETosis (65) and ROS-generation (20, 66).