TCA1, TLR7, MMP9, CXCL10, CXCL13, HLA-DRA, and ADIPOQSPP1 were expressed at significantly higher levels in the IL-1β-induced group than in the osteoarthritis group, and our data also suggest that osteoarthritis may be associated with immune responses, chemokine-mediated signaling pathways, and inflammatory responses, and these studies improve our understanding of the development of osteoarthritis. Here, MMP9 is linked to osteoarthritis.