C3 and rheumatoid arthritis: Vascular cell adhesion molecule-1 (also known as VCAM1 or CD106), the soluble form of which is associated with chronic inflammatory diseases such as rheumatoid arthritis in mammals (64, 65), coagulation factor X, and complement C3 abundances all increased in the immunized sharks at day 14 and remained at elevated levels until the end of the time course.