miR16-5p regulates HMGA1/2 and ACVR2a while miR-34b regulates HNF4A, NOTCH1, c-MET/HGFR and CAV1 and miR-99b-5p regulates RAVER2 and mTOR which are all IBD-risk genes. Here, NOTCH1 is linked to irritable bowel syndrome.