miR-205-5p targets LRRK2, SHIP2/INPPL1, ZEB1, E2F1, ERBB3 and miR-142-5p targets NFE2L2/NRF2 and miR-424-5p targets MYB, CUL2, PU.1 which are either IBD-risk loci or IBD-related known genes. The gene discussed is CUL2; the disease is irritable bowel syndrome.