Results showed that hypoxic preconditioning (HP) or IP protected the myocardium from I/R-induced cell death in the presence of CYPD, whereas it did not in the case of CYPD deficiency, and the same result occurred when CYPD was inhibited by cyclosporine A (Hausenloy et al., 2010). The gene discussed is PPIF; the disease is hyperinsulinemic hypoglycemia, familial, 4.