LZTR1 and infection: During this period, RDs were detected in the cytoplasm, as the IAV proteins M1 and NS2 (Lamb and Lai, 1980; Lamb et al., 1981) were present to enable nuclear export of vRNPs; however, given that TDs remained stationary at Hours 1–3 post-infection, but disappeared after apoptosis (Figure 4Aa–c; Supplementary Table 2), it is possible that the IAV proteins enabling vRNP nuclear export were either not expressed prior to apoptosis, or that the enlarged nuclear pores activated by IAV-induced caspase are required to enhance the nuclear export of vRNPs (Muhlbauer et al., 2015).