ANG and adenocarcinoma: Angiogenin, also known as RNase 5, is a member of the vertebrate-specific ribonuclease A (RNase A) superfamily that was first discovered in a human adenocarcinoma cell line HT-29 and has a wide range of functions, including angiogenesis, cellular processes, tumorigenesis, innate immunity, and neurodegeneration (Fett et al., 1985; Tello-Montoliu et al., 2006; Sheng and Xu, 2016).