PTK2 and osteoporosis: lnc NRON was a key bone resorption inhibitor, and knocking down NORN in osteoclasts increased bone resorption activity and alleviated osteoporosis [23]; lnc NEAT1 stimulated osteoblast differentiation, and overexpression of NEAT1 promoted the expression of PTK2 through sponging miR-7, accelerated the formation of osteoclasts, and reduced the bone mass of mice [24].