Early in tumorigenesis, the local C5a can recruit MDSCs by binding to C5aR1, thereby impairing the proliferation and function of CD8+ T cells, creating a pretumor immunosuppressive microenvironment and ultimately promoting AOM/DSS-induced mice colorectal carcinogenesis [82]; this has also been found in melanoma mice [83]. The gene discussed is C5AR1; the disease is infectious otitis media.