In skin and brain tumor models, neutrophil recruitment was dependent on CXCL8 (IL-8)/CXCR1+2 signaling [44, 45], while macrophages/microglia were recruited via CSF-1 (M-CSF) and CXCL12b (SDF1b)/CXCR4b pathways [46]. The gene discussed is CXCL8; the disease is brain neoplasm.