In another study on the administration of azoxymethane (AOM)/dextran sulfate sodium salt- (DSS-) induced colon cancer in mice, diphtheria toxin (DT) injection (for the depletion of Foxp3+ Tregs) after the last DSS cycle increased the number of CD62Llow CD8+ Teffs, accompanied by enhanced cytotoxic activity (upregulated-expression of IFN-γ and granzyme B), in the colon of mice, as well as a significant reduction in the distribution of tumors in the colon, which could be completely attenuated by CD8+ T-cell-depleting antibodies [74]. The gene discussed is CD8A; the disease is malignant colon neoplasm.