We also found that the hypoxic microenvironment drives the biological process of OC malignant progression by affecting the glycolytic pathway of cancer cells, in which WTAP regulates the miR-200 that can regulate the key gene HK2 in the the pathway by interacting with DGCR8, a key component of the canonical microprocessor complex of microRNA biogenesis. This evidence concerns the gene HK2 and cancer.