ARMS2 and age-related macular degeneration: For example, progression from early AMD to the advanced stage of AMD has been related to a set of signs, such as the number and type of (soft) drusen in the macula, drusen size, the presence of pigment irregularities in the macular, age > 65 years, previous cataract surgery, cigarette smoking, and family history of AMD (mostly due to genetic variants of CHF and ARMS2 genes).