The ratio of IFN-γ to IL-13 was significantly higher (p = 0.001) between after induction with S. pyogenes plus SLE-inducing biologics and after induction with S. pyogenes only than after induction with S. pyogenes plus non-SLE-inducing biologics and after induction with S. pyogenes only (Table 3; Figure 3). This evidence concerns the gene IFNG and systemic lupus erythematosus.