NLRP3 and diabetic kidney disease: Taking the regulatory effect of circ_0004951/miR-93-5p axis on NLRP3 into consideration, we concluded that circ_0004951 promotes pyroptosis of renal tubular epithelial cells in DKD by sponging miR-93-5p to induce activity of the NLRP3 inflammasome (Figure 6).