THY1 and ovarian cancer: However, different studies have reported that Thy-1 is downregulated in ovarian cancer tissues and that Thy-1 overexpression decreases tumor formation in vivo and anchorage-independent growth in vitro, effects that are dependent on the expression of αvβ3 integrin (Abeysinghe, Cao et al., 2003; Chen, Hsu et al., 2016).