This is possible through the interaction of endothelial Thy-1 with the αvβ3 integrin in melanoma cells, since antibodies targeting these molecules inhibit melanoma trans-endothelial migration and the adhesion of melanoma cells to the human dermal microvascular endothelial cells (HDMEC) under flow or static conditions (Saalbach, Wetzel et al., 2005). This evidence concerns the gene THY1 and melanoma.