THY1 and cancer: Since then, evidence has indicated that more physiologically relevant cell-cell interactions mediated by this Thy-1–integrin interaction exist, including 1) activated endothelial cells and cancer cells; 2) activated endothelial cells and neutrophils, monocytes; 3) activated fibroblasts and dendritic cells; 4) fibroblasts and cancer cells; as well as 5) neurons and astrocytes.