For instance, there is evidence from rodent epilepsy models, that the formation of GCD can be triggered by the loss of reelin-producing cells (Heinrich et al., 2006; Gong et al., 2007; Antonucci et al., 2008; Duveau et al., 2011; Orcinha et al., 2016). The gene discussed is RELN; the disease is epilepsy.