Reelin is a large secreted ECM glycoprotein regulating many important processes in mammalian brain development, and dysregulation of reelin signaling has been linked to several brain diseases such as autism, schizophrenia, depression, AD, and, in particular, epilepsy (Ishii et al., 2016; Hirota and Nakajima, 2017; Santana and Marzolo, 2017; Wasser and Herz, 2017; Armstrong et al., 2019; Okugawa et al., 2020; Orcinha et al., 2021). The gene discussed is RELN; the disease is major depressive disorder.