ACTR2 and hepatocellular carcinoma: Zhang Y et al. (2017) revealed the critical role of the Arp2/3 complex in surface TCR maintenance and T cell homeostasis and found that loss of ARPC2 causes a dramatic decrease in peripheral T cell numbers and compromises T cell homeostasis by disrupting the integrity of the complex. ARPC2 is also a critical driver of integrin-dependent phagocytosis and chemotaxis of macrophages. In addition, in our previous study, we demonstrated that the expression levels of ARPC2 in HCC tissues are associated with a variety of immune infiltration cells (Huang et al., 2021).