HAND1 and myocardial infarction: Recently, single-cell analysis has been used to study cell fate changes during the reprogramming of cardiomyocytes (CMs) (Liu et al., 2017), in the heart from gene knock-out animals (Nkx2.5 KO, Hand1 KO, etc.)(DeLaughter et al., 2016; de Soysa et al., 2019) or mouse model of myocardial infarction (MI), heart failure (HF), etc. (Martini et al., 2019; Wang Z. et al., 2020).