In T-ALL, the genes with a high mutation frequency were NOTCH1 (54.5%), FBXW7 (27.3%), TTN (27.3%), MUC16 (27.3%), PHF6 (18.2%), KMT2D (18.2%), EPPK1 (18.2%), FLT3 (18.2%), IL7R (18.2%), and JAK3 (7.3%). This evidence concerns the gene EPPK1 and acute lymphoblastic leukemia.