Gene mutation analysis revealed 10 genes with a high gene mutation frequency in T-ALL: NOTCH1 (54.5%), FBXW7 (27.3%), TTN (27.3%), MUC16 (27.3%), PHF6 (18.2%), KMT2D (18.2%), EPPK1 (18.2%), FLT3 (18.2%), IL7R (18.2%), and JAK3 (7.3%).Of these genes„ the mutation frequency for FLT3 mutations were slightly more frequent than previously reported (27–29), MUC16, which showed a high mutation frequency in our study, was less common in previous reports. This evidence concerns the gene PHF6 and acute lymphoblastic leukemia.