The U-test also showed (Supplementary Table 3) that PNPLA3-CG+GG, PIIINP and HA are also associated with fibrosis (z-score = 2.01, = 2.88; = 3.11; P < 0.05), while PIIINP and HA are also associated with portal inflammation (z-score = 5.8, = 5.5, P < 0.05). Here, PNPLA3 is linked to fibrosis.