PNPLA3 and Hepatic fibrosis: In adjusted model 1, we found that increasing plasma PIIINP levels (included as logarithmically transformed variable) were associated with lower eGFR values (standardized beta coefficient: −0.206; P = 0.01), independent of age, sex, PNPLA3 rs738409 genotype and histologic stage of liver fibrosis (F0 vs. F1 ≥ 1).