HMGB1 and congenital rubella syndrome: Importantly, Acupuncture intervention reversed the CRS-induced increase of HMGB1 and Iba-1 in the hippocampus of CRS rats, suggesting that acupuncture exhibited the antidepressant effect by regulating the changes of hippocampal microglia and HMGB1 levels, which is consistent with our theoretical hypothesis.