TNF and congenital rubella syndrome: However, it is worth noting that both acupuncture and escitalopram intervention could down-regulate the expression of serum TNF-α, and the escitalopram administration intervention can increase the expression of IL-10 in the hippocampus, indicating that acupuncture and could regulate the CRS-induced proinflammatory factor TNF-α and exhibited antidepressant effect.