RCAN2 and obesity due to melanocortin 4 receptor deficiency: As shown in Table 2, univariate unconditional logistic regression analysis showed that subjects with the highest tertile of RCAN2 concentrations had 1.539-fold higher risk of obesity than those with the lowest tertile of RCAN2 concentrations (OR = 2.539, 95% CI 1.546-4.170, p < 0.001).