The ROC displayed in Figure 3A represent the diagnostic value of serum RCAN2 for distinguishing the participants with obesity from controls (AUC = 0.651, 95% CI 0.594-0.708, p < 0.001, sensitivity = 55.1%, specificity = 69.5%). The gene discussed is RCAN2; the disease is obesity due to melanocortin 4 receptor deficiency.