Furthermore, in hyperglycemic milieu, MALAT1 silencing directly reduces Enhancer of Zeste homolog 2 (Ezh2), an enzyme which catalyzes dimethylation/trimethylation of histone 3 lysine 27 (90), and Ezh2 activation in diabetes helps recruit DNA methylation enzymes at the promoter of matrix metalloproteinase-9, activating its transcription (124). This evidence concerns the gene EZH2 and diabetes mellitus.