However, dietary supplementation with Nano-ZnO reduced the number of swollen mitochondria and autolysosomes, improved the shape and structure of mitochondria and down-regulated the protein expression of P62 and the ratio of LC3B to LC3A in jejunal mucosa of IUGR finishing pigs, suggesting that Nano-ZnO could reduce IUGR-induced autophagy in jejunal mucosa. The gene discussed is SQSTM1; the disease is fetal growth restriction.