Compared with the IUGR group, dietary added 600 mg Zn/kg from Nano-ZnO significantly enhanced the mRNA expression of Nrf2, GCLM, GPx1 and IL-10 (P < 0.05), and reduce the mRNA expression of TNF-α and NF-κB in jejunal mucosa of IUGR pigs (P < 0.05), while did not significantly alter the mRNA expression of Keap1, HO-1, GCLC, SOD1, IL-1β, IL-4, IL-6 and IFN-γ (P > 0.05). The gene discussed is GCLM; the disease is fetal growth restriction.