Importantly, the expression of TNF-α and NF-κB mRNA were decreased, whereas the expression of IL-10 mRNA was increased by dietary 600 mg Zn/kg from Nano-ZnO, suggesting that Nano-ZnO can inhibit the activation of the NF-κB signal in jejunal mucosa of IUGR finishing pigs, and thereby alleviate the inflammatory response of the jejunal mucosa. The gene discussed is IL10; the disease is fetal growth restriction.