Dietary added 600 mg Zn/kg from Nano-ZnO significantly decreased the protein expression of Keap1, P62 and LC3B/A, and increased the protein expressions of total Nrf2 and nuclear Nrf2 in jejunal mucosa of IUGR finishing pigs as compared with the IUGR group (P < 0.05). Here, SQSTM1 is linked to fetal growth restriction.