WEE1 and central nervous system cancer: Indeed, this has been shown in some cancers including breast cancer.7,8 Furthermore, prior studies implicated Wee1 kinase with outcome in adult glioblastoma, and Wee1 expression levels correlated inversely with overall survival (OS).3 Previously, we have shown that Wee1 is overexpressed in pediatric high-grade compared to pediatric low-grade gliomas with the highest level noted in a patient derived DIPG cell line.9