Additionally, H3.1K27M models also expressed mutant Acvr1 (G328V), which is enriched for in H3.1K27M-mutant DMG.3,4 Following birth, successfully electroporated offspring was monitored for development of neurologic symptoms related to tumor burden, at which time whole brains were harvested (Figure 1A and B, Supplementary Figure S1). The gene discussed is ACVR1; the disease is neoplasm.